Due to prospective for promethazine to reverse epinephrine’s vasopressor impact, epinephrine should NOT be used to treat hypotension associated with promethazine overdose.
Consider this medication by mouth with or with no foodstuff as directed by your medical doctor, generally each individual 4 to 6 hrs as needed. This medication is often taken with food items if belly upset happens. Consume a lot of fluids any time you use this medication Except if usually directed by your health practitioner.
Kids twelve to eighteen decades of age—Use and dose has to be determined by your medical professional. Small children youthful than 12 decades of age—Shouldn't be Utilized in these sufferers. Missed Dose Should you pass up a dose of this medicine, skip the missed dose and return to your common dosing program. Usually do not double doses.
To aid avert withdrawal, your doctor may perhaps reduce your dose slowly and gradually. Withdrawal is much more likely When you've got applied this medication for a long time (various months) or in significant doses. Notify your doctor or pharmacist instantly if you have withdrawal.
Such as, several claimed cases of Dying happened within the publish-operative period following tonsillectomy and/or adenoidectomy, and lots of of the youngsters had evidence of becoming extremely-fast metabolizers of codeine. Also, children with obstructive sleep apnea who are treated with codeine for submit-tonsillectomy and/or adenoidectomy soreness can be particularly delicate to its respiratory depressant influence. Due to the chance of daily life-threatening respiratory melancholy and Dying:
Absorption Promethazine codeine syrup Codeine is absorbed from your gastrointestinal tract with most plasma focus taking place 60 minutes article administration. The presence of a higher-fat, significant-calorie meal didn't substantially effects the PK of codeine.
The causal part of opioids in the scientific syndrome of hypogonadism is unidentified as the many health care, Bodily, Way of life, and psychological stressors that may influence gonadal hormone levels haven't been sufficiently managed for in reports carried out to date [see Adverse Reactions (six)].
Get this medication by mouth with or with out food stuff as directed by your doctor, ordinarily each four to 6 hours as wanted. This medication can be taken with meals if tummy upset takes place. Drink loads of fluids once you use this medication Unless of course usually directed by your doctor.
Read the Medication Information supplied by your pharmacist before you start using codeine/promethazine and each time you get a refill. If you have any queries, talk to your medical professional or pharmacist.
Codeine Carcinogenicity reports were being carried out with codeine. Two-calendar year scientific tests in F344/N rats and B6C3F1 mice were performed to evaluate the carcinogenic probable of codeine. No proof of tumorigenicity was noticed in male and feminine rats at codeine dietary doses approximately 70 and eighty mg/kg/working day (approximately comparable to fifteen and twenty situations, the MRHD on a mg/m2 foundation, respectively).
It is soluble in water and freely soluble in Liquor. The molecular fat is 320.88. Its molecular formula is C17H20N2S•HCl, and it has the subsequent chemical composition.
This merchandise may include inactive substances, which often can lead to allergic reactions or other challenges. Speak to your pharmacist for more facts.
Opioid analgesics and antitussives, together with codeine, one of many Lively elements in Promethazine HCl and Codeine Phosphate Oral Alternative, should not be Employed in patients with acute febrile illness associated with successful cough or in individuals with chronic respiratory illness exactly where interference with capacity to clear the tracheobronchial tree of secretions might have a deleterious effect on the affected individual’s respiratory functionality.
If this SPL includes inactivated NDCs shown through the FDA initiated compliance motion, They are going to be specified as a result.